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Comparison study between two type of formulation taking a newly formulated effervescent ciprofloxacin

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Ahmed M. A. Masaad, Majed Al robaian

This research is a formulation of the drug as an effervescent tablet by two methods (direct compression and wet granulation). The bitter taste was masked by saccharine as sweeting agent furthermore the effervescent effect of citric acid, tartaric acid and sodium bicarbonate lead to improve the taste of the drug. Also the Guar was used as binder agent lead to hide the taste (Blasé and Shah, 1993., Skraanga and Tully, 2000.). The vanillin which was used as flavoring agent also enhances the palatability (Hussain and Barcelon. 1991., Pather et al., 2002). The formulated tablets were passed all the fundamental testes in the monograph, and also microbiological sensitivity test was done against (Escherichia coli, Salmonella typhi, Salmonellapara typhi and Staphylococcus aureus ) and then the results were compared to select the suitable one. Also compression was done between two formula of wet granulation method (the binder increase concentration and die cavity when was change).This study was found that formulating the drug as effervescent tablet by wet granulation method (low binder) concentration and die cavity thirteen or twenty is the suitable one and that might be lead to increase the drug effectiveness, therapeutic effect and decrease the ciprofloxacin resistant as well as increase patient acceptability ass effervescent tablet.

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